Biological functions of hCG and hCG-related molecules
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چکیده
منابع مشابه
Biological functions of hCG and hCG-related molecules
BACKGROUND hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterio...
متن کاملhCG: Biological Functions and Clinical Applications
Human chorionic gonadotropin (hCG) is produced primarily by differentiated syncytiotrophoblasts, and represents a key embryonic signal that is essential for the maintenance of pregnancy. hCG can activate various signaling cascades including mothers against decapentaplegic homolog 2 (Smad2), protein kinase C (PKC), and/or protein kinase A (PKA) in several cells types by binding to luteinizing ho...
متن کاملHuman chorionic gonadotropin (hCG) and hyperglycosylated hCG, seven semi-independent critical molecules: A review
hCG exists in two analogous structures, as typified by the hormone hCG which binds an LH/hCG hormone receptor and the TGFß receptor binding autocrine hyperglycosylated hCG. Both share a common α-subunit and ß-subunit amino acid sequence. From the common hormone hCG and autocrine hyperglycosylated hCG structures there are seven common hCG variants with wildly varying hormone hCG or autocrine hyp...
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Deep B and R images of three Hickson Compact Groups, HCG 79, HCG 88 and HCG 95, were analyzed using a new wavelet technic to measure possible intra-group diffuse light present in these systems. The method used, OV WAV, is a wavelet technic particularly suitable to detect low-surface brightness extended structures, down to a S/N = 0.1 per pixel, which corresponds to a 5-σ-detection level in wave...
متن کاملHyperglycosylated hCG.
Hyperglycosylated hCG (hCG-H) is a glycosylation variant of the hormone hCG. Here we review all that is known about this independently functioning molecule. As discussed, it is a very different molecule to the hormone hCG. First, hCG-H is produced by cytotrophoblast cells while regular hCG is made in syncytiotrophoblast cell. Second, it is an autocrine acting directly on the cells which produce...
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ژورنال
عنوان ژورنال: Reproductive Biology and Endocrinology
سال: 2010
ISSN: 1477-7827
DOI: 10.1186/1477-7827-8-102